1P-LSD

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1-Propionyl-d-lysergic acid diethylamide (also known as 1P-LSD) is a novel psychedelic substance of the lysergamide class. It is structurally related to LSD and other novel lysergamides like 1cP-LSD, 1B-LSD, and 1V-LSD. It is thought to produce its effects by stimulating serotonin receptors in the brain, although the precise mechanism is not known.

1P-LSD has been sold online as a research chemical (also called “designer drug”) since 2015, but the original synthesis date of 1P-LSD is unknown. Unlike most research chemicals, it has no documented record in the research literature before its emergence on the online research chemical market in 2015.

It was marketed as a legal alternative to LSD alongside other novel lysergamides like ALD-52, ETH-LAD, and AL-LAD.In 2019, it became part of a group of molecules studied by the French laboratory Caulredaitens.

This hypothesis is supported by the results of a study that demonstrated 1P-LSD is metabolized to LSD in rats.^[2] This predicts a near-identical effect profile, likely differing mainly in its rate of absorption and duration. Its classical psychedelic effects and favorable tolerability has led it to become popular among novel substance users who use it interchangeably with LSD.

Very little data exists about the pharmacological properties, metabolism, and toxicity of 1P-LSD. It is presumed to have a similar toxicity and risk profile as LSD, although there are no formal studies that prove this. It is highly advised to use harm reduction practices if using this substance.

Chemistry

1P-LSD is a semisynthetic compound of the lysergamide family. It is similar to LSD and is named for the propionyl group bound to the nitrogen of the polycyclic indole group of LSD. Propionyl consists of the carbonyl chain CH₃CH₂CO- bound to an amino group.

1P-LSD is homologous to ALD-52, which holds an acetyl group bound to the nitrogen instead of the propionyl group bound at the same location. The structure of 1P-LSD contains a polycyclic group featuring a bicyclic hexahydro indole bound to a bicyclic quinoline group. At carbon 8 of the quinoline, an N,N-diethyl carboxamide is bound.