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5-MeO-DMT (5-methoxy-N,N-dimethyltryptamine) or O-methyl-bufotenin is a psychedelic of the tryptamine class. It is found in a wide variety of plant species, and also is secreted by the glands of at least one toad species, the Colorado River toad. Like its close relatives DMT and bufotenin (5-HO-DMT), it has been used as an entheogen in South America.Slang terms include Five-methoxy, the power, bufo, and toad venom.buy 5-meo dmt online UK , Order 5-meo-DMT England , Where to buy 5 meo dmt Powder Scotland , Purchase DMT Northern Ireland , Buy dmt Wales
Chemistry
5-MeO-DMT was first synthesized in 1936, and in 1959 it was isolated as one of the psychoactive ingredients of Anadenanthera peregrina seeds used in preparing Yopo snuff. It was once believed to be a major component of the psychoactive effects of the snuff, although this has recently been shown to be unlikely, due to the limited or sometimes even non-existent quantity contained within the seeds, which instead achieve their psychoactivity from the O–demethylated metabolite of 5-MeO-DMT, bufotenin. It is metabolized mainly by CYP2D6.
Pharmacology
5-MeO-DMT is a methoxylated derivative of DMT. While most common psychedelics are believed to primarily elicit psychological effects through agonism of serotonin 5-HT2A receptors, 5-MeO-DMT shows 1000-fold greater affinity for 5-HT1A over 5-HT2A;In line with its affinity for 5-HT1A receptors, 5-MeO-DMT is extremely potent at suppressing the firing of dorsal raphe 5-HT neurons. Further, its activity in rats was attenuated with the 5-HT1A selective antagonist WAY-100635 while 5-HT2A selective antagonist volinanserin failed to demonstrate any change.Additional mechanisms of action such as inhibition of monoamine reuptake may be involved.A 2019 European study with 42 volunteers showed that a single inhalation produced sustained enhancement of satisfaction with life, and easing of anxiety, depression, and post-traumatic stress disorder (PTSD). A 2018 study demonstrated that a single dose of 5-MeO-DMT induced neurogenesis in mice.buy 5-meo dmt online UK , Order 5-meo-DMT England , Where to buy 5 meo dmt Powder Scotland , Purchase DMT Northern Ireland , Buy dmt Wales
Be careful!
- 5-MeO-DMT can induce challenging effects and aftereffects in some individuals, including spontaneous “reactivations” of the experience.
- 5 can produce significant psychological distress in some people or under some circumstances, particularly if used carelessly or in an unsafe environment.
- The casual use of 5-MeO-DMT has led to several preventable deaths, usually from people asphyxiating on vomit when using alone. 5’s intense out-of-body experience can result in a person physically moving around without conscious control.
- Combining 5-MeO-DMT with other drugs, particularly stimulants (even one after the other), has resulted in deaths as well. Even on its own 5-MeO-DMT (and particularly the bufo extract) has occasionally caused seizures in some people.
- WARNING: 5-MeO-DMT should never be combined with monoamine oxidase inhibitors (MAOIs). MAOIs can be found naturally in plants like harmine, harmaline, and Syrian rue, or in prescription antidepressant medications. MAOI is also a critical ingredient in ayahuasca. This combination can cause serious adverse reactions including death.buy 5-meo dmt online UK , Order 5-meo-DMT England , Where to buy 5 meo dmt Powder Scotland , Purchase DMT Northern Ireland , Buy dmt Wales
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