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Fluoxetine is a type of antidepressant known as a selective serotonin reuptake inhibitor (SSRI). It’s often used to treat depression, and sometimes obsessive compulsive disorder and bulimia.

It works by increasing the levels of serotonin in the brain. Serotonin is thought to have a good influence on mood, emotion and sleep.

Fluoxetine helps many people recover from depression, and it has fewer side effects than some other antidepressants.

Fluoxetine is available only on prescription. It comes as tablets, capsules, or a liquid that you swallow.

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Key facts

  • Fluoxetine usually takes around 4 to 6 weeks to work.
  • Common side effects include feeling sick, headaches and trouble sleeping. These side effects are usually mild and go away after a couple of weeks.
  • If you and your doctor decide you should stop taking fluoxetine, your doctor may recommend reducing your dose gradually. This helps to prevent withdrawal side effects.
  • Some people cannot concentrate properly while taking fluoxetine. It might be best to stop driving, cycling or using machinery for the first few days of treatment until you know how this medicine makes you feel.
  • Fluoxetine will not change your personality, it will simply help you feel like yourself again.

    IMPORTANT WARNING:

    A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants (‘mood elevators’) such as fluoxetine during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). Children, teenagers, and young adults who take antidepressants to treat depression or other mental illnesses may be more likely to become suicidal than children, teenagers, and young adults who do not take antidepressants to treat these conditions. However, experts are not sure about how great this risk is and how much it should be considered in deciding whether a child or teenager should take an antidepressant.

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    You should know that your mental health may change in unexpected ways when you take fluoxetine or other antidepressants even if you are an adult over 24 years of age. You may become suicidal, especially at the beginning of your treatment and any time that your dose is increased or decreased. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: new or worsening depression; thinking about harming or killing yourself, or planning or trying to do so; extreme worry; agitation; panic attacks; difficulty falling asleep or staying asleep; aggressive behavior; irritability; acting without thinking; severe restlessness; and frenzied abnormal excitement. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own.

    Your healthcare provider will want to see you often while you are taking fluoxetine, especially at the beginning of your treatment. Be sure to keep all appointments for office visits with your doctor.

    The doctor or pharmacist will give you the manufacturer’s patient information sheet (Medication Guide) when you begin treatment with fluoxetine. Read the information carefully and ask your doctor or pharmacist if you have any questions.

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    No matter your age, before you take an antidepressant, you, your parent, or your caregiver should talk to your doctor about the risks and benefits of treating your condition with an antidepressant or with other treatments. You should also talk about the risks and benefits of not treating your condition. You should know that having depression or another mental illness greatly increases the risk that you will become suicidal. This risk is higher if you or anyone in your family has or has ever had bipolar disorder (mood that changes from depressed to abnormally excited) or mania (frenzied, abnormally excited mood) or has thought about or attempted suicide. Talk to your doctor about your condition, symptoms, and personal and family medical history. You and your doctor will decide what type of treatment is right for you.

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